Raum 01-230 (Gebäude Recht und Wirtschaft I) Tel. Group (closed) – BA Erziehungswissenschaften, Uni Mainz. eBook - JaSeAn. Morris OT, Duch C, Stevenson PA (1999) Reflex activation of locust octopaminergic modulatory neurons by proprioreceptors responsive to flight muscle contractions. Mainz, Renânia-Palatinado, Alemanha: Presidente Georg Krausch Total de estudantes: 37 039 Página oficial website oficial: A Universidade Johannes Gutenberg de Mainz (em alemão: Johannes Gutenberg-Universität Mainz) é uma instituição de ensino superior localizada em Mainz, no estado da Renânia-Palatinado, Alemanha. (3)Institute of Developmental Biology and Neurobiology, Johannes Gutenberg University Mainz, 55099 Mainz, Germany; ryglewsk@uni-mainz.de cduch@uni-mainz.de. eNeuro. Börner J, Duch C (2010) A standard neuroanatomy atlas for the adult Drosophila ventral nerve cord. Duch C, Pflueger HJ (1999) DUM neurons in locust flight: a model system for amine mediated peripheral adjustments to a central motor program. www.uni-mainz.de. Consequently, normal brain function relies on the correct regulation of single neuron properties, such as their synaptic connections, morphology, and … Duch C, Levine RB (2002) Changes of calcium signaling during postembryonic dendritic growth in Manduca sexta. Eur J Neurosci 23:335-349. Evers JF, Muench D, Duch C (2006) Developmental relocation of presynaptic terminals along distinct types of dendritic filopodia. Cell Tissue Res 334:477-498. eNeuro. Alles zur Johannes-Gutenberg-Universität Mainz und ihren 204 Studiengängen. Mol Neurobiol 29:303-320. J Neurophysiol 102:41-58. Eur J Neurosci, 37(6):860-75. Biozentrum 1 Hanns-Dieter-Hüsch-Weg 15, 2nd Floor, Room 02.356 D 55128 Mainz Mo. Mainz [1] [2] [3] ou Mogúncia [4] [5] (em alemão: Mainz, em latim: Mogontiacum, em francês: Mayence) é uma cidade da Alemanha, capital do estado federal de Renânia-Palatinado. PLoS One, 7(2):e31835. University Information Security and Privacy © 2020 The Arizona Board of Regents on behalf of The University of Arizona.The University of Arizona. J Neurosci Methods 15:168(1):64-70. Duch's work group at Mainz University is investigating dendritic structures and functions using the fruit fly Drosophila as a model organism. Page-Name:IDN Homepage Last Update:12.October 2017 Cell Tissue Res 325:175-87. Pflueger HJ, Duch C (2011) Dynamic neural control of insect muscle metabolism related to motor behavior. Kuehn C, Duch C (2008) Expression of two different isoforms of fasciclin II during postembryonic central nervous system remodeling in Manduca sexta. Cell Biology, JGU Mainz: Albrecht Clement Inst. J Comp Neurol 422:1-17. * Shared last author. J Comp Physiol A: 196(1):37-50. With approximately 32,000 students (2018) in about 100 schools and clinics, it is among the largest universities in Germany. J Neurosci 15:1109-1113. Uni Mainz. Physiology, UM Mainz: Amparo Acker-Palmer Cell Biology, GU Frankfurt: Eva-Maria Albers Dept. Look up the English to German translation of uni Mainz in the PONS online dictionary. Biozentrum 1 Hanns-Dieter-Hüsch-Weg 15, 2nd Floor, Room 02.352 55128 Mainz Tel: +49 6131/3923419 Fax: +49 6131/3925443 e-mail: cduch@uni-mainz.de. Duch C 2 Affiliations . J Neurosci 20:6950-6961. Vierk R, Pflueger HJ, Duch C (2009) Differential effects of octopamine and tyramine on the central pattern generator for Manduca flight. Duch, Univ.-Prof. Dr. Carsten Address: Hanns-Dieter-Hüsch-Weg 15,55128 Mainz Building: BioZentrum I (1578) Room: 02-352 Phone: +49 6131 39 23419 Neurons are the building blocks of the brain. Hutchinson K, Vonhoff F, Duch C (2014) Dscam1 is required for normal dendrite growth and branching but not for dendritic spacing in Drosophila motoneurons. Williams AA, White R, Sniard A, Corneveaux J, Huentelman M, Duch C (2016) MECP2 impairs neuronal structure by regulating KIBRA. PNAS 116(9):3805-3810. Gaitanidis A, Dimitriadou A, Dowse H, Sanyal S, Duch C, Consoulas C. (2019) Longitudinal assessment of health-span and pre-death morbidity in wild type Drosophila. Vonhoff F, Duch C (2010) Tiling Among Stereotyped Dendritic Branches in an Identified Drosophila Motoneuron. Accordingly, dendritic defects are consistent anatomical correlates of numerous brain diseases, but specific causality remains unproven. and the secretary: Renate Bertgen. Ryglewski S, Duch C, Altenhein B (2017) Tyramine Actions on Drosophila Flight Behavior Are Affected by a Glial Dehydrogenase/Reductase. Duch C, Vonhoff F, Ryglewski S (2008) Dendrite elongation and dendritic branching are affected separately by different forms of intrinsic motoneuron excitability. Neurobiol of Disease, in press. The biogenic amines octopamine (OA) and tyramine (TA) modulate insect motor behavior in an antagonistic manner. PNAS 111(50):18049-54. J Neurophysiol 102(6):3673-88. Fax +49 6131 39-25548. J Comp Physiol A: 195(3):265-77. doi: 10.1523/ENEURO.0181-19.2019. Ryglewski S, Kadas S, Hutchinson K, Schuetzler N, Vonhoff F, Duch C (2014) Dendrites are dispensable for basic motoneuron function but essential for fine tuning of behavior. Int Comp Biol 46:E36. Ryglewski S, Duch C (2012) Preparation of Drosophila Central Neurons for in situ Patch Clamping. Biogenic amines, like norepinephrine, can act as neuromodulators to render animal behavior adaptive to changing external and internal conditions. Lukas Kilo, Ph.D. Student, kilo@uni-mainz.de Mol. Burkert P, Duch C (2006) Developmental changes of CaMKII localization, activity and function during postembryonic CNS remodeling in Manduca sexta. Burg Lahneck. Group (open) – Master Erziehungswissenschaft, Uni Mainz. Neuron 93(3):632-645.e6. Duch C, Pflueger HJ (1995) Motor patterns for horizontal and upside down walking and vertical climbing in the locust. Neurons are the building blocks of the brain. J Physiol 593(22):4871-88. Meseke M, Evers JF, Duch C (2009) Postembryonic dendritic remodeling of an identified neuron is accompanied by changes in synapse distribution and dendritic input computation. eCollection 2018. DEGREE COURSE: Guide to the Bachelors and Masters Degree Programs Kühn C, Duch C (2013) Putative Excitatory and Putative Inhibitory Inputs Localize to Different Dendritic Domains in a Drosophila Flight Motoneuron. Ryglewski S, Vonhoff F, Scheckel K, Duch C (2017) Intra-neuronal Competition for Synaptic Partners Conserves the Amount of Dendritic Building Material. ℹ️ mail.uni-mainz.de receives about 38,037 unique visitors per day, and it is ranked 25,698 in the world. Email: cduch@uni-mainz.de Search for more papers by this author Approximately 100 billion neurons in our brain form 100 trillion synapses onto 100,000 miles of dendritic cable. Ryglewski S, Lance K, Levine RB, Duch C (2012) Cav2 Channels Mediate LVA and HVA Calcium Currents in Drosophila Motoneurons. Die rechteckige Kernburg ist von vier Gebäudeflügeln und einer Schildmauer mit Ecktürmen umgeben. Duch C, Mentel T, Pflueger HJ (1999) Distribution and activation of different types of octopaminergic DUM neurons in the locust. Herrera-Valdez MA, McKiernan EC*, Berger SD*, Ryglewski S, Duch C, Crook S (2013) Relating ion channel expression, bifurcation structure, and diverse firing patterns in a model of an identified motor neuron. Libersat F, Duch C (2002) Morphometric analysis of dendritic remodeling in an identified motoneuron during postembryonic development. 2. J Neurophysiol 79:361-370. The University of Mainz (full name Johannes Gutenberg University Mainz) (German: Johannes Gutenberg-Universität Mainz) is a public research university in Mainz, Rhineland Palatinate, Germany, named after the printer Johannes Gutenberg since 1946. Die Entfernung von Graffiti kostet die Johannes Gutenberg-Universität jährlich rund 80.000 Euro. Front Syst Neurosci 11:68, Kadas D, Klein A, Krick N, Worrell JW, Ryglewski S, Duch C (2017) Dendritic and Axonal L-Type Calcium Channels Cooperate to Enhance Motoneuron Firing Output during Drosophila Larval Locomotion. Group (private) – Master of Education, Uni Mainz. Development 140(3):606-16. Mit Erfahrungsberichten, NC-Liste und zulassungsfreien Studiengängen. J Physiol J Physiol 590(Pt 4):809-25. Duch C (2006) Form and function of identified insect motoneurons. Homepage. However, the mechanisms and cellular targets of TA modulation of locomotor activity are incompletely understood. 55099 Mainz Germany. Current project. Johannes Gutenberg University Mainz was originally founded in 1477 and today still strives to emulate the innovational spirit of its namesake. OA generally enhances locomotor behaviors such as Drosophila larval crawling and flight, whereas TA decreases locomotor activity. Die spätstaufische Burg der Erzbischöfe und Kurfürsten von Mainz wurde um das Jahr 1245 zum Schutz des Gebiets an der Lahnmündung erbaut. Advising by appointment only. Hohensee S, Bleiss W, Duch C (2008) Correlative electron and confocal microscopy assessment of synapse localization in the central nervous system of an insect. J Neurophysiol 87:1415-1425. Ryglewski S, Pflueger HJ, Duch C (2007) Expanding the Neuron’s Calcium Signaling Repertoire: Intracellular Calcium Release via Voltage induced PLC and IP3R Activation. Stocker B, Bochow C, Damrau C, Mathejczyk T, Wolfenberg H, Colomb J, Weber C, Ramesh N, Duch C, Biserova NM, Sigrist S, Pflüger HJ. We are interested in the functional diversity of voltage gated calcium channels and its implications for normal neurophysiology ans behavior. Background: To compare the efficacy and safety of timolol 0.5% versus brinzolamide 1.0% when added to travoprost monotherapy in patients with primary open-angle glaucoma or ocular hypertension. E-Mail. Kadas D, Duch C, Consoulas C. (2019) Postnatal Increases in Axonal Conduction Velocity of an Identified Drosophila Interneuron Require Fast Sodium, L-Type Calcium and Shaker Potassium Channels. Vierk R, Pflueger HJ, Duch C (2010) Postembryonic development of centrally generated flight motor patterns in the hawkmoth, Manduca sexta. However, in a computing, adapting, and learning system such as the brain, these properties must also retain functional plasticity. The promotion and introduction of new ideas, the use of knowledge to improve people’s lives and encourage them to overcome the many boundaries they encounter daily – these are the underlying ambitions of Johannes Gutenberg University Mainz. mail.uni-mainz.de links to network IP address 134.93.178.3. Mar 19;12:5. doi: 10.3389/fnsys.2018.00005. doi: 10.1523/ENEURO.0181-19.2019. Kadas D, Duch C, Consoulas C. (2019) Postnatal Increases in Axonal Conduction Velocity of an Identified Drosophila Interneuron Require Fast Sodium, L-Type Calcium and Shaker Potassium Channels. Duch C, Mentel T (2004) Activity affects dendritic shape and synapse elimination during steroid induced dendritic regression in Manduca sexta. J Neurophysiol 100(5):2525-36. Aging (Albany NY). J Comp Neurol, 518:2437-2455. Additional information about this page. Group leader. J Comp Neurol, 518:2169-2185. Ryglewski S, Duch C (2009) Shaker and Shal mediate transient calcium-independent potassium current in a Drosophila flight motoneuron. Bayline RJ, Duch C, Levine RB (2001) Nerve-muscle interactions regulate motor terminal growth and myoblast distribution during muscle development. J Insect Physiol 54(1):240-54. : +49 (0) 6131 / 39 - 21979 Fax: +49 (0) 6131 / 39 - 23 004. J Comp Physiol 195(5):473-89. Close affiliations . To address these questions we use Drosophila melanogaster as a model system. Physiology (Bethesda) 26:293-303. PLoS Biol 5(4):e66. Schmitt S, Evers JF, Scholz M, Duch C, Obermayer K (2004) New methods for the computer assisted 3D reconstruction of neurons from confocal image stacks. J Exp Biol 198:1963-1976. Prof. Dr. Carsten Duch. Perturbations cause dendrite shifts and result in defects of adaptive motor control. Mainz é uma cidade independente ( kreisfreie Stadt ) ou distrito urbano ( Stadtkreis ), ou seja, possui estatuto de distrito ( … Logo der Johannes Gutenberg-Universität Mainz, Zusätzliche Informationen zu dieser Seite. J Neurosci 27(41):11122-31. Brain Res Bulletin 53:571-583. Wären Kameras an besonders betroffenen Stellen … Besucheranschrift / Office: Hanns-Dieter-Hüsch-Weg 15 (Gebäude 1578, 2.Stock, 02-352) 55128 Mainz Here we genetically remove dendrites in Drosophila motoneurons, followed by analysis of functional outcomes. E-mail: sac@unieducar.org.br Fone: 0800.005.3005 Escritório em São Paulo - SP: Av. Duch C, Mentel T (2003) Motoneuron terminal retraction and outgrowth depend on stage-specific activity patterns during the metamorphosis of Manduca sexta. Pathobiochem., UM Mainz: Carsten Duch Inst. (2)Institute of Molecular Biology, Johannes Gutenberg University Mainz, 55099 Mainz, Germany. J Exp Biol 202:3555-3564. J Neurosci 34(5):1924-31. Logo der Johannes Gutenberg-Universität Mainz, Zusätzliche Informationen zu dieser Seite. Brembs B, Christiansen F, Pflueger HJ, Duch C (2007) Flight initiation and maintenance deficits in flies with genetically altered biogenic amine levels. Hotline +49 6131 39-22122. Baudoux S, Duch C, Morris OT (1998) Coupling of efferent neuromodulatory neurons to rhythmical leg motor activity in the locust. Corresponding author C. Duch: Institute of Neurobiology, Johannes Gutenberg University of Mainz, Col.‐ Kleinmann Weg 2, 55099 Mainz, Germany. Institute of Neurobiology, Johannes Gutenberg University of Mainz, 55099 Mainz, Germany. J Neurophysiol 93:2331-2342. Ryglewski S, Kilo L, Duch C (2014) Sequential acquisition of cacophony calcium currents, sodium channels and voltage-dependent potassium currents affects spike shape and dendrite growth during postembryonic maturation of an identified Drosophila motoneuron Eur J Neurosci, 39(10):1572-85. mail.uni-mainz.de uses Microsoft HTTPAPI web technologies. Duch C, Levine RB (2000) Remodeling of membrane properties and dendritic architecture accompany the postembryonic conversion of a ‘slow’ into a ‘fast’ motoneuron. E-Mail: joerg.korff@uni-mainz… Mentel T, Duch C, Müller U, Stypa H, Wegener G, Pflueger HJ (2003) Fuel selection in locust flight muscle by the activity of central modulatory neurons. J Comp Neurol 450:153-166. Evers JF, Schmitt S, Scholz M, Duch C (2005) New frontiers in functional neuroanatomy: precise automatic reconstruction from confocal image stacks. Each neuron must acquire a specific ‘Gestalt’ and a defined set of ion channels during development and maintain them within critical ranges throughout life. University Information Security and Privacy © 2020 The Arizona Board of Regents on behalf of The University of Arizona.The University of Arizona. Acta Biol Hung 51:343-348. Meseke M, Evers JF, Duch C (2009) PTX-induced hyperexcitability affects dendritic shape and GABAergic synapse density but not synapse distribution during Manduca postembryonic motoneuron development. Consequently, normal brain function relies on the correct regulation of single neuron properties, such as their synaptic connections, morphology, and membrane currents. Gaitanidis A, Dimitriadou A, Dowse H, Sanyal S, Duch C, Consoulas C. (2019) Longitudinal assessment of health-span and pre-death morbidity in wild type Drosophila. Dev Biol 231:348-363. Therefore, even with a complete connectome in hand, understanding brain function requires an intricate analysis of the physiology and functional morphology of its component neurons. Vonhoff F, Kühn C, Blumenstock S°, Sanyal S, Duch C (2013) A precise temporal coherency between receptor expression, neural activity, and AP-1 dependent transcription regulates dendrite development in an identified Drosophila motoneuron. University Medical Center Mainz | 2,450 followers on LinkedIn. Pflueger HJ, Duch C (2000) The functional role for octopaminergic neurons in insect motor behavior. Consoulas C, Duch C, Bayline RJ, Levine RB (2000) Behavioral transformations during metamorphosis: remodeling of neural and motor systems. Find more data about mail. European J Neurosci 17:1-18. J Comp Neurol 403:119-134. Somos uma instituição de Educação que atua nas áreas de Treinamento em Desenvolvimento Profissional e Gerencial desde fevereiro de 2003. 9.00-12.00) Tel. J Comput Neurosci 34(2):211-29. When analyzing the role of dendrites, the experimental challenge is to abolish them selectively in identified Drosophila wing motoneurons without affecting other properties of these specific neurons or others. Dev Biol 297(1):214-227. 1990-1994 Study of Biology, Free University Berlin 1994 Diploma of Biology, Free University Berlin 1995-1998 PhD Student at the Institute of Neurobiology, Free University Berlin 11(6):1850-1873. doi: 10.18632/aging.101880. Acta Biol Hung 55:3-12. Synapses determine information processing between neurons, whereas electrical properties as well as structure determine information processing within neurons. Neuroimage 23:1283-1298. Börner J , Puschmann T, Duch C (2006) A steroid hormone affects sodium channel expression in Manduca central neurons. J Neurosci 24:9826-9837. report that competitive mechanisms are required to correctly partition synaptic inputs from different transmitter systems on the dendritic arbor of a Drosophila motoneuron. Includes free vocabulary trainer, verb tables and pronunciation function. Duch C, Bayline RJ, Levine RB (2000) Development of the DLM flight motor system in Manduca sexta. awiercze@students.uni-mainz.de, anna.wierczeiko@lir-mainz.de. Schützler N, Girwert C, Hügli I, Mohana G, Roignant JY, Ryglewski S*, Duch C* (2019) Tyramine action on motoneuron excitability and adaptable tyramine/octopamine ratios adjust Drosophila locomotion to nutritional state. • determine the functional consequences of correct and false regulation of neuronal properties for synaptic integration, neuronal firing patterns, and behavior in the healthy and in the diseased brain. Adrenergic signaling profoundly modulates animal behavior. - Fr. J Vis Exp 15;(68). Exkursion LL BiMA. J Neurosci 37(45):10971-10982. Johannes Gutenberg-Universität Mainz Jakob-Welder-Weg 9 55099 Mainz. Institute of Neurobiology, Johannes Gutenberg University of Mainz, Mainz, Germany. Corresponding Author. Kadas D, Ryglewski S, Duch C (2015) Transient BK outward current enhances motoneurone firing rates during Drosophila larval locomotion. 1. (2018) Structural and Molecular Properties of Insect Type II Motor Axon Terminals. Please note: Due to the amount of requests reaching the “Studierendenservice” at the moment there is a delay up to one week in answering them. Nove de Julho, 5229 - 5° Andar Vonhoff F, Williams A, Ryglewski S, Duch C (2012) Drosophila as a Model for MeCP2 Gain of Function in Neurons. J Comp Physiol A 184:489-499. Libersat F, Duch C (2004) Cellular and molecular mechanisms of the maturation of neuronal dendritic trees. Fields L, Duch C, Pflueger HJ (2007) Reflex activation of octopaminergic unpaired median neurons in the locust. Inst. We use the versatile genetic model system Drosophila melanogaster for our research. Front Syst Neurosci. Pflueger HJ, Duch C, Heidel E (2004) Neuromodulatory octopaminergic neurons and their functions during insect motor behaviour. To understand the adaptive regulation of these properties our research objectives are: • identify the molecular mechanisms that regulate electrical and morphological properties of neurons. Methods: Patients meeting selection criteria (IOP one eye 19 mmHg and ≤32 mmHg and IOP both eyes ≤32 mmHg at 8:00 h) were switched to travoprost monotherapy for 4 weeks. Arbeitsgruppe/Research team Prof. Dr. C. Duch. Arbeitsgruppe von der Theorie zur Forschungspraxis. Kathryn Scheckel, Carsten Duch Correspondence cduch@uni-mainz.de In Brief Ryglewski et al. Toplinks. In addition to the unprecedented genetic tools available in Drosophila, the transformation from the larval to the adult stage during metamorphosis is a striking example of postembryonic nervous system plasticity and remodeling, and the functions of individually identified neurons can directly be related to stage specific behaviors. Proceedings of the National Academy of … The Ernst Florey memory lecture. Stefanie Ryglewski, Ph.D., ryglewsk@uni-mainz.de. Dutta S, Rieche F, Eckl N, Duch C, Kretzschmar D (2015) Glial expression of Swiss-Cheese, the Drosophila orthologue of Neuropathy Target Esterase, is required for neuronal ensheathment and function. Unravel Resilience - Using Multi-Omics Integration to explore the Molecular Background of Stress Resilience Resilience is the ability to cope with stress or to quickly recover to pre-crisis state after being exposed to extreme stress. Disease Models & Mechanisms, Dec 3 [Epub ahead of print]. Institute of Neurobiology, Johannes Gutenberg University of Mainz, 55099 Mainz, Germany cduch@uni-mainz.de.